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While moderate physical effort is beneficial in reducing the risk of chronic and inflammatory diseases by modulating the activity of protein kinases such as the mammalian target of rapamycin (mTOR) or AMP-activated protein kinase (AMPK) and the serum levels of inflammatory markers such as leptin, adiponectin, ghrelin, interleukin-6 (IL6), interleukin-1 (IL1), and tumor necrosis factor (TNF), strenuous physical exertion has the opposite effect, with direct repercussions on mitochondrial metabolism [11,12]

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