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In AD mouse models, CMS121 significantly reduces hippocampal 4-hydroxynonenal, a lipid peroxidation marker linked to neuronal damage (281), while decreasing glial fibrillary acidic protein expression, indicating attenuated glial activation (282)

Currently, the exploration of ferroptosis in bone and joint diseases has focused mainly on cell and animal models, and future research should pay more attention to clinical studies

[DOI] [PubMed] [Google Scholar] 251.Wang L, Du J, Zhou Y, Wang Y

doi: 10.1093/hmg/ddh323
