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This is why an oral B12 supplement might do nothing for your fatigue, but a B12 injection makes you feel different by that afternoon

Tran, N., Garcia, T., M Aniqa, Ali, S., Ally, A., & SM Nauli

Adverse reactions following intramuscular (IM) injection have included anxiety, mild transient diarrhea, ataxia, nervousness, pruritus, transitory exanthema, and a feeling of swelling of the entire body

The study found that up to around half of all autoimmune thyroid patients had a vitamin B-12 deficiency
