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Cancer cells preferentially colonized distal niches including the caudal hematopoietic tissue (CHT), mimicking organotropic metastasis to hematopoietic microenvironments

Oxidative StressInduced Cellular Senescence Excessive ROS induces oxidative damage to various biomolecules, especially DNA, which is the quintessential signal for senescence induction [132]

IGF1R deficiency decreases proliferation, DNA damage, senescence, and vascularization, attenuates tumor invasion by reduced EMT and fibrosis, and induces apoptosis upon pulmonary metastasis To determine the effect of IGF1R deficiency in the metastatic TME, we immunostained lung tumors of LLC-challenged mice for the following markers: Ki67 (proliferation), 53BP1 (DNA damage), p21 (senescence), C3 (apoptosis), CD31 and CD34 (vascularization), SOX9 (epithelial-mesenchymal transition, EMT), as well as Vimentin, Fibronectin, SMA and Masson (fibrosis)

How could these findings change our clinical practice