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10.3390/cells10113252 86 MatasA
For example, KAR5585 (rodatristat ethyl) has emerged as a promising first-in-class oral tryptophan hydroxylase 1 (TPH1) inhibitor

This regulatory mechanism underscores DJ-1s crucial role in cellular defense against oxidative stress, highlighting its potential as a therapeutic target for neurodegenerative diseases and conditions involving oxidative damage (Ge et al., 2022

10.1093/jrr/rrad084 97