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It typically presents as macrocytic megaloblastic anemia and neurological impairments, including sensory and motor disfunctions, predominantly in the lower extremities, ataxia, and in more advanced stages cognitive decline progressing to dementia, as well as psychiatric disturbances (Green et al., 2017)
The procedure generally lasts 1530 minutes, depending on the number of trigger points treated

Stimuli-Responsive In Situ Gelling System for Nose-to-Brain Drug Delivery
