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Cisplatin-induced downregulation of OCTN2 affects carnitine wasting

Animal models of obesity and T2D as well show affected BCAA catabolism [75, 111, 112]: tissue-specific expression of BCAA-catabolic enzymes are shown to be dysregulated [23, 27, 79, 108, 113,114,115,116,117,118,119,120,121] especially in adipose tissue [75, 122] and liver [75, 113]

Moreover, IL-6 modulates claudin-2 protein expression through IL-6R-associated signaling transducers and gp130 signaling pathway, consequently enhancing TJ permeability in intestinal epithelium (129)

Statistical analysis We obtained the Wald estimate (genetic association with CVD and its risk factors divided by the genetic association with l-carnitine) for each SNP