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By targeting multiple mechanisms, this approach promotes a more consistent growth hormone (GH) and insulin-like growth factor 1 (IGF-1) response

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Results GSDMD-mediated pyroptosis is activated in ischemic hindlimbs To investigate the involvement of GSDMD-mediated pyroptosis in hindlimb ischemic injury in vivo, we established hindlimb ischemia (HLI) model by ligation of the femoral artery in wild-type (WT) mice