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The evidence for meaningful additional benefit from niacinamide inclusion is limited, but like glycine, it adds minimal cost and no significant risk
For weight loss specifically, additional escalation beyond 1.0mg provides additional benefit, but 1.0mg is the floor of effective dosing for most people
Wang B, Han X, Lin X, Wang J, You C, Chen K, et al
Th17 cells and inflammation in neurological disorders: possible mechanisms of action
