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We have shown that effective pharmacologic inhibition of GPX4 in PTC cells with direct inhibitor RSL3 induces a robust activation of ferroptosis, increased DNA damage, impaired DNA damage repair response due to reduced p-NPM1 levels, decreased cell viability and cell migration, as well as suppressed spheroid formation and viability in vitro

SOD2 encodes superoxide dismutase two that neutralizes O 2 - generated during oxidative phosphorylation ( SOD2 polymorphism, rs4880 located in exon 2, introduces a T to C substitution at position 2,734, resulting in the SOD2 Ala16Val genotype

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Es stellt den entscheidenden Schutz der Zell- und Mitochondrienmembranen vor der Schdigung durch reaktive Sauerstoffspezies (oxidativer Stress) dar