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(2016) reported that the absence of BMAL1 in mice not only disrupts circadian rhythms but also increases oxidative stress, impairs mitochondrial function, and perturbs metabolic pathways, pointing to a clock-independent role for BMAL1 in maintaining redox balance, proteostasis, and tissue integrity

Newer alternative treatments for sickle cell anemia include crizanlizumab (Adakveo) which is a monoclonal antibody therapy

Experimental studies indicate that supraphysiological testosterone exposure increases reactive oxygen species generation within cardiomyocytes while reducing the activity of endogenous antioxidant enzymes, including superoxide dismutase and glutathione peroxidase (72)