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10.1016/j.jhep.2020.04.038 132 SoutoJ

The substantial weight reduction observed with tirzepatide monotherapy (15-21% body weight in clinical trials) suggests that any perceived benefits likely reflect tirzepatide's pharmacological effects rather than synergistic action

In other words, if you come back for treatment before the benefits have gone away, you will notice the effects to last longer and longer over time
