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C., McCullough, S

J Hainan Med Univ 25(4):6164 Latini A, Borgiani P, De Benedittis G, DAmato C, Greco C, Lauro D, Novelli G, Spallone V, Ciccacci C (2020) Mitochondrial DNA copy number in peripheral blood is reduced in type 2 diabetes patients with polyneuropathy and associated with a MIR499A gene polymorphism

Some lipid oxidation studies have also been recently done in coarse grained models, which have derived bilayer elastic coefficients (compressibility and bending) for oxidized membranes 15 , and the effect of cholesterol on protecting oxidized membranes 18

Given the rich lipid content of the nervous system, hemoglobin-derived iron works with lipid peroxidation to induce ferroptosis, which eventually leads to neuronal mitochondrial damage, edema, and apoptosis of neurons and astrocytes