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In cases where oxidative stress is the pathophysiological basis, some natural antioxidant products work through different mechanisms than conventional drugs do to enhance therapeutic efficacy, avoiding the need to add new drugs to basal therapies, thus achieving therapeutic goals at lower doses of standard therapies (191)
Glycated hemoglobin (HbA1C) 6.5% or greater
for example, PKM2 activates the HIF-1 transcription factor by modulating ATP levels required for tumor cell proliferation, thereby promoting glycolysis
