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195 In summary, GATA1 promotes autophagy and mitophagy during erythroid differentiation, whereas GATA4 inhibits autophagy in cardiomyocytes and enhances inflammatory signaling during senescence

Mutations in SMARCA4 and SMARCA2 genes, therefore, affect chromatin accessibility and the expression of genes linked to differentiation, DNA repair, and epithelial-mesenchymal transition (EMT), ultimately disrupting epigenetic regulation and promoting tumor progression (Ma et al

gingivalis lipopolysaccharide activates downstream inflammatory factors and transcriptional networks via the Toll-like receptor 4 (TLR4)/NF-B pathway, leading to upregulation of the ACSL4/LPCAT3 axis ( Conversely, monounsaturated fatty acids (MUFAs) provide membrane stability due to their lack of readily oxidizable bis-allylic hydrogen atoms