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2 A recent clinical epidemiological study showed that local anesthesia can potentially interferes with human permanent tooth development and induces tooth agenesis through unknown mechanisms

J.et al (2024)

The neuroprotective effects of the ketogenic diet further extend to synaptic plasticity regulation: by increasing -hydroxybutyrate (BHB) levels, it directly activates the ERK/CREB signaling pathway in the hippocampus, promoting brain-derived neurotrophic factor (BDNF) synthesis (especially in females) to restore impaired long-term potentiation (LTP) in Alzheimers model mice

PMID 18484522 Shin, S
