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Using in vivo and ex vivo ischemia-reperfusion models, ozone treatment was shown to reduce myocardial injury by regulating ferroptosis-related proteins and transcription factors, particularly enhancing Nrf2 nuclear translocation, thereby exerting cardioprotective effects ( 3.1.5 Mechanisms of ferroptosis in myocardial ischemia-reperfusion injury In pathological conditions such as myocardial ischemia-reperfusion injury, the Nrf2/Keap1 pathway becomes dysregulated, leading to the dissociation of Nrf2 from Keap1 and its subsequent translocation into the nucleus
Schotsaert M, De Filette M, Fiers W, Saelens X

Pomegranate Extract Pomegranate is packed with polyphenols that reduce oxidative stress by scavenging free radicals and promoting antioxidant activity.(14) References: Homocysteine-lowering by B-vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial by Smith AD, Smith SM, de Jager CA, Whitbread P, Johnston C, Agacinski G, Oulhaj A, Bradley KM, Jacoby R, Refsum H
J Australian Chiro Assn
