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doi: 10.1007/s00210-024-03179-4 166 MehtaSBoyerTLAkhtarSHeTZhangCVedadghavamiAet al

After neomycin-induced hair cell loss, Wnt activity as indicated by the TOP;GFP reporter transgene increases, and this rise coincides with the increase in proliferation observed in supporting cells in the neuromasts (Head et al., dkk1b dampened the proliferative response to hair cell damage, suggesting that Wnt signaling was required at least for the mitotic phase of regeneration

In these models, sulforaphane promoted resilience by preventing pro-inflammatory cytokine production and associated adverse consequences

Furthermore, compared with the HCD group, the HCD + ALC group showed significantly decreased Srebp2 , Hmgcr , Ldlr , Apob , and Abcg8 mRNA levels and a significantly increased Abcg5 mRNA level (Figure 3H)