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Both the SWI/SNF inhibitor AU-15330 and the mitochondrial complex I oxidative phosphorylation inhibitor IACS-010759 showed pronounced synergy with bi-steric mTORC1 inhibitors to cause cuproptotic cell death in RP/MRD cells, suggesting these combinations as a potential patient treatment strategy for rapalog resistance

"That's why this discussion is so important and why the FDA's authority here is an important one to exercise appropriately with optimal outside advice," he says.

Cancer 10 (7), e004147