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After reading the complete version of these 42 selected articles, 13 other studies, which were cited in the articles evaluated, but were not obtained in the search, were included, totalizing 55 articles44 original studies and 11 literature reviews (Figure 1)

A growing body of evidence links it to the onset and progression of various neurodegenerative diseases (NDs), including AD, Parkinsons disease (PD), demyelinating multiple sclerosis (MS), as well as cerebrovascular disorderswhether acute ischemic stroke, nontraumatic intracerebral hemorrhage, or hemorrhage in the cerebral sulci

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