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Clinical guidelines for interstitial cystitis and hypersensitive bladder updated in 2015

Intact bacteria, antigens, and particulate matter are transported by specialized M-cells overlying intestinal lymphoid aggregates (Peyers patches) in the distal small intestine [16,17,18] and are sensed by goblet cell-associated antigen pathways (GAPs) [19], with some data indicating that LPS is absorbed through the lamina propria by GAPs in the small intestine [20]

Needles that have a larger diameter also have thicker walls

And anyway the authors of the Cochrane Review state that the patient should absorb the 1% passively should, not will