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Macia L, Tan J, Vieira AT, Leach K, Stanley D, Luong S, Maruya M, McKenzie CI, Hijikata A, Wong C

In contrast, under oxidative stress conditions, the oxidation of Keap1 cysteine residues alters its binding to Nrf2, and Nrf2 translocates to the cell nucleus to induce the transcription of antioxidant genes [19]

Other potential adverse effects of high dose and long-term glutathione supplementation include: Lightening of hair colour: A logically expected effect since hair colour is dependent on the amount and type of melanin which may be altered by glutathione supplementation