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Natural occurrence as well as possibilities of glutamate-like biological activity modulated by additional hydrogen bonding with hydroxy groups inspired the interest in the synthesis of stereoisomers of hydroxyglutamic acids 2 4 (Figure 2)
The biology of vascular endothelial growth factors
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10.1016/j.neuroscience.2004.06.031 [DOI] [PubMed] [Google Scholar] Andreotti J