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3 At 50mg, GHK-Cu activates collagen synthesis pathways, supports skin matrix integrity, improves skin texture and elasticity, and provides cellulite reduction support through its role in collagen and connective tissue regeneration

40,66 It also acts as an agonist primarily at 5-HT 1a serotonin receptors and to a lesser extent at 5-HT 2a receptors

Cytokines like tumor necrosis factor (TNF) are the main means by which these activated cells foster a chronic inflammatory state and impact processes like neo-angiogenesis, epidermal hyperproliferation, differentiation, and apoptosis

The expression of IL-1, IL-8, and keratin 16 in the herbal extract group was significantly decreased (Yang et al., 2021)