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The most common measurements of liver function used in the studies were AST and ALT ( n = 12 studies) and TBil or bilirubin ( n = 12)

In vitro and animal studies have found that lipoic acid exhibits immunomodulatory properties through mechanisms that stimulate the production of cyclic AMP (cAMP) (90, 91) a central regulator of innate immune functions and inhibits the migration of immune cells into the brain and spinal cord (92), possibly by decreasing endothelial expression of cell adhesion molecules, inhibiting expression of enzymes like matrix metalloproteinases (MMP), and/or reducing the permeability of the blood-brain barrier (87, 89, 93, 94)

Cheignon C, Tomas M, Bonnefont-Rousselot D et al (2018) Oxidative stress and the amyloid beta peptide in Alzheimers disease