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This limitation matters because repeated-dose toxicity guidelines normally expect systematic clinical observations, body weight tracking, hematology, clinical chemistry, organ weights, and histopathological examination under a defined study design

J.KirkhamC.ZhongH.SethiS.MunsonR.S.Jr (2011)

Without enough B12, you might experience persistent fatigue, muscle weakness, numbness or tingling, and even issues with memory or concentration
