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A mitochondria-targeted covalent organic framework (COF) prodrug that is selectively activated by high intramitochondrial GSH levels was shown to trigger catalase collapse within the organelle, thereby amplifying local chemodynamic therapy (CDT) through enhanced ROS accumulation and mitochondrial dysfunction

Elevated levels of cell surface PDK1 have been observed in aggressive cancer types, including lung cancer, gastric cancer, and myeloma (Anwar et al., 2021)

[DOI] [PMC free article] [PubMed] [Google Scholar] Heidet M

Reactive oxygen species/glutathione dual sensitive nanoparticles with encapsulation of miR155 and curcumin for synergized cancer immunotherapy