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In cardiovascular disease progression, areas of vascular damage are typically characterized by elevated local ROS (61)

Concretely, GPX4 uses GSH as the substrate to reduce phospholipid hydroperoxides (PLOOHs) to hydroxyl derivatives (PLOHs), and oxidizes GSH to GSSH, therefore alleviating the damage of oxidative stress to tumor cells ( As a case in point, Li and co-workers loaded dihydroartemisinin (DHA) into iron-based MOFs to design a peroxidase-like nanoreactor (termed DHA@MIL-101 NR) for synergistic CDT-ferroptotic therapy (Figure 5C) ( 3+ , achieving GSH consumption-mediated redox reaction and Fe 2+ -mediated Fenton reaction (Figure 5D)

Always consult with your healthcare provider before starting any new supplement, especially if you are taking prescription medications like nitroglycerin or anticoagulants, or if you have underlying health conditions