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The initial study based on surveys 156 was conducted almost 10 years ago and has yet to be confirmed or refuted by more rigorous studies

This can help to identify any changes or trends over time and allow for appropriate adjustments in treatment or management

Expression of micronutrient deficiencies in ASD Frequently overlooked are the data demonstrating that endogenous aldehydes induce localized, intracellular deficiencies in a subset of micronutrients, which either initiate oxidative stress (multiple sulfur-containing antioxidants, Zn 2+ ) or serve as cofactors (B1, B6, folate, and Zn 2+ ) in the metabolic pathways implicated in autism: neurotransmitter functions, DNA methylation, chromatin remodeling, transcriptional regulation, and neuronal development