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Exercise has been known to attenuate oxidative stress and improve diabetic complications due to its effects on mitochondrial carbohydrate and lipid metabolism ( Our earlier study on GK rats subjected to moderate exercise training has shown improvement in cardiac muscle contractile dysfunction and relaxation in myocytes, which are relevant to improvement in diabetes-induced myocardial dysfunction ( Exercise training is recognized as an important non-therapeutic strategy in the management of type 2 diabetes, and studies have shown its effects on mitochondrial metabolic, oxidative, and redox functions in different tissues

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Lactoferrin is well tolerated in very young newborns, is straightforward to administer, and serves as a reference for lactoferrin supplementation in clinical practice (161)