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FSP1 functions independently of GSH, reducing coenzyme Q10 (CoQ10) to CoQ10H2 via NADPH, which quenches lipid peroxyl radicals and inhibits ferroptosis even in the absence of GPX4 (Lv et al., 2023

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Moskalev A, Chernyagina E, Tsvetkov V, Fedintsev A, Shaposhnikov M, Krutko V, Zhavoronkov A, Kennedy BK (2016a) Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic