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To increase aqueous solubility of the compounds to facilitate structural studies, the cycloheptyl substituent in TGR uncompetitive inhibitor 8 was replaced with a sugar moiety, resulting in compound 9 , a noncompetitive inhibitor and thus capable of binding the enzyme in absence of NADPH

[DOI] [PubMed] [Google Scholar] 57.Cazzola M., Calzetta L., Page C., Jardim J., Chuchalin A.G., Rogliani P., Matera M.G

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Importantly, the group that took the placebo was observed to have a significant increase in MDA levels in RBCs ( Figure 4E )