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The NPEY motif in the juxtamembrane region in both IR and IGF1R is critical for recruitment of receptor substrates including IRS-1 and Shc (16, 17)

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Encapsulation within CS-NPs confers multiple advantages, including improved aqueous solubility, protection from enzymatic degradation and pH variations in the GI tract, controlled and sustained release of phytoconstituents, and enhanced intestinal absorption through prolonged GI residence mediated by mucoadhesive properties, collectively augmenting the oral bioavailability and bioactivity (96)