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88,89 At this time, polyethylene glycol is not Food and Drug Administration-approved nor guideline-recommended (AASLD 2014) for the treatment of HE, though it is mentioned as possible alternative therapy pending further study

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By identifying a core set of 62 cross-validated mitochondrial genes and establishing high-confidence metabolite-gene correlations (notably MTHFR-homocysteine and PDHA1-acetyl-CoA), the authors demonstrate significant sex-dimorphic flux alterations within the tricarboxylic acid (TCA) cycle and mitochondrial transport subsystems, particularly pronounced in females

In parallel, microRNAs (miRNAs) have emerged as crucial regulators of inflammatory and metabolic pathways that further modulate these processes