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These modifications may act downstream of core circadian regulators or be orchestrated by ubiquitin ligases and deubiquitinating enzymes that themselves may be under circadian control
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To deliver rivastigmine to treat Alzheimers disease via the nose-to-brain route, Cunha et al developed different lipid-based nanoparticles, nanoemulsions (RIV-NE), and NLCs (RIV-NLC)
