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Short-term CDK4/6 inhibition under low-stress conditions typically leads to reversible quiescence, while prolonged inhibition or high oncogenic or oxidative stress favours irreversible senescence

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Alpha Lipoic Acid (ALA):Promotes energy metabolism and helps reduce oxidative stress

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Our intervention experiments on PAJs revealed that blocking pleural ECM from invading alleviates and reverse fibrosis progression, leading to healthier lung architecture

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