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Rats were pretreated with icv scopolamine (70 nmol in 2 aCSF) 20 min prior to training followed 15 minutes later by an ip injection of dihexa in DMSO ( 1 %) at .05mg/kg, .25mg/kg, or .50mg/kg

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Two exercise studies based on blood samples are noteworthy since they tracked intraindividual changes or examined purified exosomes: In the first study, an increase of the pro-inflammatory cytokines IL-6 and IL-1 at 8 h after exercise was predictive of higher post exercise fatigue scores (White et al., 2010) (IL-6 and IL-1 trigger glial reactivity)