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Despite the fact that peptide ligands are relatively flexible and have a lower binding affinity to receptors compared with antibodies, the use of peptides in theranostic nanomedicine offers advantages because they are smaller, have reduced immunogenicity, have high multivalency, penetrate deep into tumors, are simpler to synthesize, and are cost-effective in production

Conditional inactivation of the BMP type IA receptor in epithelial stem cells located in the bulge region of HF induced overproduction of HF stem/progenitor cells and the genetic manipulation of the BMP signaling pathway caused the activation of -catenin, suggesting that BMP activity regulates the HF cycle by antagonizing Wnt/-catenin pathway [15]

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