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Because RB1 is a major downstream effector of CDK4/6 signaling, RB1 loss in cancer cells contributes intrinsic resistance to CDK4/6i 1,10,11,12,13,14
doi:10.1111/j.1365-2958.2009.06955.x 47
Enterocytes continually generate low-grade inflammation as part of this process [33]
Since both address different concerns, they can be used on alternate days
