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MRI findings often show LS-like features, with symmetrical necrotic lesions in the basal ganglia and brainstem (96)
Therefore, during oxidative stress, glutathione depletion enhances ascorbate synthesis to protect against oxidative damage [80]
NAC has multiple protective mechanisms, including: increasing glutamate transport into glial cells, increasing extra-synaptic glutamate release via activation of mGlu2/3, and antioxidant effects as the precursor to glutathione [214]
Hashimotos is not usually discovered until it has progressed to the advanced stages, where there is significant damage to the thyroid gland
