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Reasons underlying the pathogenesis of ASD are still not well understood, but recent studies point to the influence of epigenetic dysregulation in ASD development, which opens up avenues to novel diagnosis and treatment options

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Collectively, NOXs and the ETC generate roughly 85% of H 2 O 2 , with the remaining production deriving from oxidases in the endoplasmic reticulum (ER) and peroxisomes, as well as from cumulative environmental stressors such as UV or ionising radiation 8,40,42,43

Rare: hypotension, peripheral ischemia, angina