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Therefore, copper may induce SAW through mitochondria-related pathways such as PI3K/AKT/mTOR, FOXO, JAK-STAT, NF-B, AMPK-mTOR, and others (Figure 2)

examined the effect of different levels of NAC diet on antioxidant factors and oxidative stress in Wistar rats and the results showed that in all groups receiving NAC with different doses, serum paraoxonase-1 level was increased

Evidently, intracellular cyst(e)ine contribute to ferroptosis suppression via at least two additional pathways in different contexts: in a mouse lung adenocarcinoma model, NFS1 cysteine desulfurase utilizes cysteine to synthesize ironsulfur clusters, which are necessary for preventing activation of the iron-starvation response, subsequent iron influx and ferroptosis 14 (Fig

GCL consists of a catalytic subunit, GCLC, and a modifier subunit, GCLM