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The adoption of large-scale collaborative research, standardization of definitions and analyses, pilot examination of interventions, and improvement in study design standards, peer review, reporting, and dissemination of research have been identified as crucial actions to enhance the validity of scientific works (302)

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[Crossref] Canavese M, Altruda F, Ruzicka T, Schauber J (2010) Vascular endothelial growth factor (VEGF) in the pathogenesis of psoriasis--a possible target for novel therapies

However, these do have to be prescribed and administered by a healthcare professional, and are more likely to be given to people who have lifelong conditions affecting their ability to absorb B12 or who are at higher risk of consistent deficiency