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As shown in Supplementary Figure S6, this seemingly discrepancy might be explained in terms of MSP primers coverage that interrogate only three CpG positions (not included in our pyrosequencing analysis), two in the forward and one in the reverse primers

This may also be preferred by those who experience issues related to oral antibiotic use (antibiotic resistant pathogens, deteriorated gut health etc)

The experimental results showed that the tumor volume and weight of the RRM2 overexpression group were significantly higher than those of the control group, and immunohistochemistry showed up-regulation of the expression of proliferation markers (e.g., Ki67, PCNA), which was in line with the previous observation that RRM2 promotes cell proliferation in tumors such as breast and lung cancers, and further corroborated the promotional role of RRM2 in tumorigenesis and development

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