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Description
In addition to IGF pathways, anti-tumor effects on PI3K/AKT/mTOR and MAPK/ERK pathways with metformin exposure were observed, leading to the upregulation of markers of cell cycle arrest, apoptosis, and autophagy and downregulation of markers associated with senescence and the inhibition of cell migration (Hanna et al., 2012

[DOI] [PubMed] [Google Scholar] 185.Kim YJ, Park YJ, Lee YM, Rhyu IC, Ku Y

But if your skin is sensitive or reactive, Alpha Arbutin might be a safer choice

Int J Radiat Biol (2015) 91(9):70314
