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Specifically, insufficient VEGF signaling may disrupt the intricate balance of vasodilation and vasoconstriction, crucial for maintaining optimal blood flow to the brain regions

Key Points Intervertebral disc (IVD) degeneration is frequently associated with low back and neck pain The avascularity of the IVD is an obstacle to intrinsic repair by exogenous cells Tissue-specific progenitor cells have been identified in the IVD, and these cells could be targeted to promote intrinsic repair Supplementation of functional cells from exogenous sources has IVD-regenerative effects in basic and preclinical studies A growing number of clinical trials are assessing the effects of cell therapy for IVD disease Despite promising results of cell therapy for IVD disease in preclinical studies, various obstacles remain to define its efficacy and target indications Abstract Intervertebral disc (IVD) degeneration is frequently associated with low back and neck pain, which accounts for disability worldwide