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493 Additionally, to address soft tissue sarcoma resistance to PDT, ZTN@COF@poloxamer nanocapsules were developed, integrating a Zr-based MOF, the photosensitizer Tetrakis (4-carbethoxyphenyl) porphyrin, and the PARP inhibitor Niraparib, where light-activated ROS generation induces apoptosis, enhancing PDT efficacy and blocking DNA repair