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RXRalpha ablation in epidermal keratinocytes enhances UVR-induced DNA damage, apoptosis, and proliferation of keratinocytes and melanocytes

PubMed , Cruzat, Vinicius, et al

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This position of Nrf2 for polyubiquitination by the Cul3-RBX-1 complex marks it for proteasomal degradation, maintaining a low level of Nrf2 under normal conditions
