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A revision is warranted as more evidence emerge relating genotype with phenotype, genetic variant classes and enzyme activity, and discovery of novel mutations

408 Within this complex interplay of diet, metabolism, and inflammation, IL-17 has been identified as a key player in metabolic dysregulation associated with HFD, where inhibiting IL-17A production or blocking its receptor can attenuate obesity by enhancing adipose tissue browning and energy dissipation

Higher doses of vitamin B 12 supplements are recommended for patients taking medications that interfere with its absorption (see Drug interactions)

2017;170(3):457-469 e13