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Oral sildenafil in the treatment of erectile dysfunction
metabolic syndrome and inflammation on the one hand and heart failure on the other hand
Therefore, as circulating LCACs have been independently associated with CVDs and type 2 diabetes, the intersection of these two associations with the pathogenesis and progression of diabetic cardiomyopathies is currently unknown

Current serotonin medications are aimed at increasing central 5-HT neurotransmission in the brain, and there are no approved indications for manipulating peripheral 5-HT, though peripheral 5-HT synthesis is being considered as a potential target for developing pharmacological agents in some disorders (8, 9)